Kinase Inhibitors from Marine Sponges
نویسندگان
چکیده
Protein kinases play a critical role in cell regulation and their deregulation is a contributing factor in an increasing list of diseases including cancer. Marine sponges have yielded over 70 novel compounds to date that exhibit significant inhibitory activity towards a range of protein kinases. These compounds, which belong to diverse structural classes, are reviewed herein, and ordered based upon the kinase that they inhibit. Relevant synthetic studies on the marine natural product kinase inhibitors have also been included.
منابع مشابه
Molecular docking and druggability studies of terpenoid-derived metabolites from marine sponges as IL-17A inhibitors
In this study, physicochemical properties of 49 compounds extracted from anti-inflammatory sponge species with the aim of ADMET test and Lipinski rule of five have been determined. Fourteen compounds, which showed best results, were subjected to molecular docking studies with IL-17. Among these compounds, Four compounds with low binding energy were obtained. These compounds, namely, frondosins ...
متن کاملMarine Sponges and Bacteria as Challenging Sources of Enzyme Inhibitors for Pharmacological Applications
Enzymes play key roles in different cellular processes, for example, in signal transduction, cell differentiation and proliferation, metabolic processes, DNA damage repair, apoptosis, and response to stress. A deregulation of enzymes has been considered one of the first causes of several diseases, including cancers. In the last several years, enzyme inhibitors, being good candidates as drugs in...
متن کاملChemical characterization, antioxidant and inhibitory effects of some marine sponges against carbohydrate metabolizing enzymes
UNLABELLED BACKGROUND More than 15,000 marine products have been described up to now; Sponges are champion producers, concerning the diversity of products that have been found. Most bioactive compounds from sponges were classified into anti-inflammatory, antitumor, immuno- or neurosurpressive, antiviral, antimalarial, antibiotic, or antifouling. Evaluation of in vitro inhibitory effects of d...
متن کاملIdentificationof sponges of inter tidal zone in North of Hengam Island, Persian Gulf
In this study marine sponges of inter tidal zone from Hengam Island Persian Gulf were collected by wading at low tides in Eskeleh station at locations 55˚ 53ʹ 40ʺ E & 26˚ 40ʹ 53ʺ N.For identifying identification of sponge samples, acid digestion method as a method of early detection and microtome section to identify the skeletal structure were used.All the identified sponges were from class De...
متن کامل